This website is about PD. A few months ago I noticed a number of articles showing a strong correlation between PD and prostate cancer surgery, i.e. radical prostatectomy (RP). When I published these articles, I never imagined that the response would be so overwhelming. In response to the overwhelming response, I published a follow up edition primarily covering the same topic. (Type "Prostate" into the search box for much more information) This often seems like a case of the tail wagging the dog as the topic prostate cancer has taken over the readership of this website. The majority of visitors to this site now come because they are researching prostate cancer and their feedback concerns their surprise (shock, dismay) at developing PD and associated symptoms, such as penile shortening, loss of girth, after having treatment for prostate cancer. What is most disconcerting is that these men had no idea that these conditions could result from their treatment. It appears that any significant trauma to the prostate and surrounding areas increase the chances of developing Peyronie like symptoms. If you go to prior issues of this site, it also seems that urologists are often unaware that their treatment can result in PD.
I am not suggesting that men do not follow the advice of their urologists concerning treatment, but informed consent is an integral part of the process. There is no doubt this is a weak link in the treatment system and am surprised there is not more legal action by men who suffer these outcomes. This is still a PD website, but since there is so much interest in this topic, I will continue to devote part of the site to prostate cancer.
Can radiation therapy promote the development of PD? According to the Journal of Urology, (ISSN 0022-5347) the answer is apparently yes. First two definitions.
Cytokines - hormone like proteins that regulate the intensity and duration of immune responses. Over expression can lead to scarring
Fibroblast - capable of forming collagen fibers
A factor involved in the development of PD is fibrotic cytokine over expression. Cell culture cells were irradiated and demonstrated the basic fibroblast growth factor when compared to the control. Conclusion: These data suggest that radiation may in fact increase the production of fibrogenic cytokines, which may promote the fibrotic process involved in PD
In a previous edition of this website, it was reported that a case study conducted in 2008 demonstrated that men who underwent a RP had a significant likelihood of developing PD This study published in the Medical News today reported that the incidence of post RP men who developed PD was 17%. A more recent study in the Journal of Sexual Medicine confirms this correlation with a RP and PD. A database of 1011 men who attended a sexual medicine clinic after undergoing a RP was reviewed and the PD incidence rate was 15.9%. Mean time to develop PD after PR was approximately 13.9 months. Younger, white men seemed mostly at risk.
There is significant anecdotal evidence from my feedback that men are developing these symptoms. Here are just some email comments I have received.
comment = I was diagnosed with Prostate Cancer in April of 2004. I had 34 External Beam Radiation Treatments. After the treatments my gland reduced in size, and my discharge became clear as water. My PSA never fell below 2.66, then began to rise rapidly. I began Hormone Deprivation Therapy in February 2008. The side effects were distressing. About five months ago I discovered two depressions of the right side of my penis. It no longer pointed straight ahead, but leaned to the right. I experienced some discomfort during intercourse, and did use Viagra to help me with some degree of Erectile Dysfunction. My Urologist has examined me, and feels that I do have a mild case of Peyronies. I understand that it may heal on its own. Prior to developing the two depressions in my penis, I measured about 6 1/2 inches in length. Now, I barely measure 5 inches. This has brought me great distress, and my penis slightly arcs downward, which makes penetration into my wife's vagina a little d! ifficult. I would really like to know if the radiation could have caused this, or if the hormone deprivation may have been the cause. And, if it may cure on its own, and if my penis will ever recover to its original length
comments = Desperate men around the world are being 'duped' into paying ten's of thousands of dollars for H.I.F.U. Many think High Intensity Focused Ultrasound is the "miracle" cure for prostate cancer,with very little risk .However, no one ever discusses the risk of peyronies. Many Doctors only offer surgery or say sorry ,there is no known cure.
Comment : I had my prostrate done with the TURP method but suffers all the symptoms of peyronies disease and penile shortening. It is now two years later and there is no change. The worse is that I have no sensation in my penis at all. Is this normal and can it be cured?